双硫死亡（Disulfidptosis）

双硫死亡（Disulfidptosis）

双硫死亡是一种在葡萄糖匮乏时由二硫化物应激引发的新型程序性细胞死亡，其特征是由于二硫化物积聚导致的细胞骨架蛋白和F-肌动蛋白坍塌。SLC7A11介导的胱氨酸摄入抑制铁死亡，但在葡萄糖匮乏时诱导双硫死亡（图1）。

Disulfidptosis, a new form of programmed cell death triggered by disulfide stress under glucose starvation, is characterized by the collapse of cytoskeleton proteins and F-actin due to the intracellular accumulation of disulfides. SLC7A11-mediated cystine uptake suppresses ferroptosis yet induces disulfidptosis under glucose starvation (Fig.1).

图1 双硫死亡发生机制示意图¹

Fig.1 Schematic diagram of molecular mechanisms for disulfidptosis¹

本司提供以下方法检测双硫死亡（葡萄糖匮乏情况下）：

We use following methods to detect disulfidptosis under glucose starvation:

参考文献（Reference）

1    Zheng, P., Zhou, C., Ding, Y. & Duan, S. Disulfidptosis: a new target for metabolic cancer therapy. J Exp Clin Cancer Res 42, 103 (2023). https://doi.org:10.1186/s13046-023-02675-4