泛凋亡（PANoptosis）

泛凋亡（PANoptosis）

泛凋亡是新近发现的一种炎症性程序性细胞死亡，受到泛凋亡小体（PANoptosome）的调控，具有凋亡、程序性坏死以及焦亡的关键特征，但不能被凋亡、程序性坏死以及焦亡中任意一种死亡方式单独表征（图1）。

PANoptosis is a newly discovered inflammatory programmed cell death that is regulated by the PANoptosome. It has key characteristics of apoptosis, necroptosis and pyroptosis, but cannot be independently characterized by any one of apoptosis, necroptosis and pyroptosis (Fig.1).

图1 泛凋亡发生机制示意图¹

Fig.1 Schematic diagram of molecular mechanisms for PANoptosis¹

本司提供以下方法检测泛凋亡：

We use following methods to detect PANoptosis:

参考文献（Reference）

1    Zheng, M. & Kanneganti, T. D. The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis). Immunol Rev 297, 26-38 (2020). https://doi.org:10.1111/imr.12909