程序性坏死（Necroptosis）

程序性坏死（Necroptosis）

程序性坏死是一种非凋亡的炎症性程序性细胞死亡，即受调控的坏死形式。程序性坏死过程由混合谱系激酶域样（Mixed-lineage kinase-like，MLKL）蛋白磷酸化介导，并由细胞表面死亡受体以及RNA和DNA传感分子的激活启动（图1）。

Necroptosis is a nonapoptotic form of programmed inflammatory cell death and a regulated form of necrosis. The necroptotic process depends on the phosphorylation of mixed-lineage kinase-like (MLKL), which is initiated by the activation of cell surface death receptors and RNA- and DNA-sensing molecules (Fig.1).

图1 程序性坏死发生机制示意图¹

Fig.1 Schematic diagram of molecular mechanisms for necroptosis¹

本司提供以下方法检测程序性坏死：

We use following methods to detect necroptosis:

参考文献（Reference）

1    Tong, X. et al. Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research. J Hematol Oncol 15, 174 (2022). https://doi.org:10.1186/s13045-022-01392-3