凋亡（Apoptosis）

凋亡（Apoptosis）

凋亡是最常见的程序性细胞死亡，可程序性有效清除受损细胞，比如DNA损伤或发育过程产生的细胞。凋亡可由含半胱氨酸的天冬氨酸蛋白水解酶（Cysteinyl aspartate specific proteinase, caspase）介导的外源性（配体/死亡受体）或内源性（线粒体）通路触发（图1）。

Apoptosis is the most common form of programmed cell death leading to the orderly and efficient removal of damaged cells, such as those resulting from DNA damage or during development. Apoptosis can be triggered in a cell through either the caspase-mediated extrinsic (ligands/death receptor) or intrinsic (mitochondrial) pathways (Fig.1).

图1 凋亡发生机制示意图¹

Fig.1 Schematic diagram of molecular mechanisms for apoptosis¹

本司提供以下方法检测凋亡：

We use following methods to detect apoptosis:

参考文献（Reference）

1    Pistritto, G., Trisciuoglio, D., Ceci, C., Garufi, A. & D'Orazi, G. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging (Albany NY) 8, 603-619 (2016). https://doi.org:10.18632/aging.100934